Our Research Interest

Organic molecules have various physical and biological properties derived from their structures, and therefore the construction of such molecules by reasonable and efficient ways has been an important issue in organic synthesis. Our research group explores novel organic reactions and novel molecular properties by employing organic active species such as cations, radicals, anions, carbenes, etc. as key components. We also study the biological properties of the synthesized functionalized molecules as bioimaging probes in vitro as well as contrast agents in vivo.

Introduction of our research in 2020 (pdf, in Japanese)


【Current research topics】
- Transition metal-catalyzed reactions for construction of heteroaromatics
Heteroaromatics are attractive organic compounds and applied as biological as well as electronic materials. We are exploring new and efficient transition metal-catalyzed reactions to construct heteroaromatics from accessible starting compounds.

Divergent Catalytic Approach from Cyclic Oxime Esters to Nitrogen-Containing Heterocycles with Group 9 Metal Catalysts
Takuya Shimbayashi, Gaku Matsushita, Atsushi Nanya, Akira Eguchi, Kazuhiro Okamoto,* and Kouichi Ohe*
ACS Cat., 8, 7773-7780 (2018).doi.org/10.1021/acscatal.8b01646


- Dinuclear transition metal complexes generated from alkyne-containing bisphosphine ligands
New types of transition metal complexes always show new reactivities. We synthesized dinulear complexes bearing newly-designed alkyne-containing bisphosphine ligands. We are exploring their new reactivities especially in chiral transformation.

Bimetallic Reactivities of Dinuclear Iridium and Rhodium Complexes Generated from Two Types of Alkyne-containing Bisphosphine Ligands
Kohei Sasakura, Kazuhiro Okamoto,* and Kouichi Ohe*

Eur. J. Inorg. Chem., 2020, 1894-1901. DOI: 10.1002/ejic.202000132

- Stimuli-responsive molecular probes for evaluation of biological process
We are designing and synthesizing new types of stimuli-responsive probes for detection of biological processes, especially enzyme and physiological conditions (pH). We are currently exploring dual-responsive molecular probes for detection of cancer stem cells and so on.

Substituted meso-Vinyl-BODIPY as Thiol-Selective Fluorogenic Probes for Sensing Unfolded Proteins in the Endoplasmic Reticulum
Huiying Mu, Koji Miki,* Takuya Kubo, Koji Otsuka,
and Kouichi Ohe*
Chem. Commun., in press. DOI: 10.1039/D0CC08160D

Table of contents-Mu-cc-final

An enzyme-triggered turn-on fluorescent probe based on carboxylate-induced detachment of a fluorescence quencher
Masahiro Oe, Koji Miki,* and Kouichi Ohe*
Org. Biomol. Chem., 2020, 18, 8620-8624. DOI: 10.1039/d0ob00899kmetallic
Cover Picture に選ばれました.

スクリーンショット 2020-10-23 18.54.06屏幕快照 2020-12-21 下午6.50.42

- Tumor imaging contrast agents in vivo
We are focusing on the synthesis of contrast agents for optical and photoacoustic tumor imaging and tomography. By applying stimuli-responsive probes, we recently reported the activatable photoacoustic contrast agent for detection of acidic environment in tumors.

pH-Activatable Cyanine Dyes for Selective Tumor Imaging Using Near-infrared Fluorescence and Photoacoustic Modalities
Huiying Mu,
Koji Miki,* Hiroshi Harada, Kouki Tanaka,
Kohei Nogita, and Kouichi Ohe
ACS Sens., 2021, 6, 123-129. doi.org/10.1021/acssensors.0c01926